Health Minster Mike Nesbitt has sacked the chair of the Belfast Trust, Ciaran Mulgrew.
The Department of Health said Mr Nesbitt decided on a change of leadership at the trust, saying he believes a fresh start is required.
The minister and department said they would like to thank Mr Mulgrew for his contribution to the trust and the wider health and social care system.
Mr Mulgrew will leave the post on Friday and the department said the process for filling the chair's post is being initiated as a priority.
In a statement, Belfast Trust's interim chief executive Maureen Edwards said she would like to extend “my sincere thanks to Ciaran for his unwavering support, contribution and commitment during his time as trust chairman”.
She said Mr Mulgrew had helped the trust through some challenging times since his appointment.
“In particular, he has shown courage and leadership over the last few months in bringing focus and committing to addressing issues around culture and behaviours in our organisation,” she said.
“Ciaran always acknowledges the fantastic work of staff in Belfast Trust and is proud of their many achievements. He is leaving the organisation with our gratitude and best wishes for the future.
“I wish * to reassure our staff and the public that we will continue to make tangible improvements across the organisation to benefit * staff, patients and service users.”